MovDisordV3, Main, Exploration, bibRecord, 002515

Homocysteine and Cognitive Impairment in Parkinson's Disease: A Biochemical, Neuroimaging, and Genetic Study

Identifieur interne : 002515 ( Main/Exploration ); précédent : 002514; suivant : 002516

Homocysteine and Cognitive Impairment in Parkinson's Disease: A Biochemical, Neuroimaging, and Genetic Study

Auteurs : Mariac. Rodriguez-Oroz [Espagne] ; Pablo Martinez Lage [Espagne] ; Jose Sanchez-Mut [Espagne] ; Isabel Lamet [Espagne] ; Javier Pagonabarraga [Espagne] ; Jon B. Toledo [Espagne] ; David Garcia-Garcia [Espagne] ; Pedro Clavero [Espagne] ; Lluis Samaranch [Espagne] ; Cecilia Irurzun [Espagne] ; Juan M. Matsubara [Espagne] ; Jaione Irigoien [Espagne] ; Emilia Bescos [Espagne] ; Jaime Kulisevsky [Espagne] ; Jordi Perez-Tur [Espagne] ; Jose A. Obeso [Espagne]

Source :

Movement disorders [ 0885-3185 ] ; 2009.

RBID : Pascal:09-0358934

Descripteurs français

Pascal (Inist)
- Trouble cognitif, Maladie de Parkinson, Démence, Déficit cognitif léger, Pathologie du système nerveux, Homocystéine, Substance blanche, Hyperintensité.

English descriptors

KwdEn :
- Cognitive disorder, Dementia, Homocystein, Hyperintensity, Nervous system diseases, Parkinson disease, White matter, mild cognitive impairment.

Abstract

The role of the plasma level of homocysteine (Hcy), as a primary outcome, and the effect of silent cerebrovascular lesions and genetic variants related to Hcy metabolism, as secondary outcomes, in the cognitive decline and dementia in Parkinson's disease (PD) were studied. This casecontrol study focused on 89 PD patients of minimum 10 years of evolution and older than 60 years, who were neuro-psychologically classified either as cognitively normal (n = 37), having mild cognitive impairment (Petersen criteria) (n = 22), or suffering from dementia (DSM-IV) (n = 30), compared with cognitively normal age-matched control subjects (n = 30). Plasma levels of Hcy, vitamins B12 and B6, folic acid, polymorphisms in genes related to Hcy metabolism (MTHFR, MTR, MTRR, and CBS) and silent cerebrovascular events were analyzed. Plasma levels of Hcy were increased in PD patients (P = 0.0001). There were no differences between the groups of patients. The brain vascular burden was similar among PD groups. There was no association between polymorphisms in the studied genes and the Hcy plasma levels or cognitive status in PD patients. We found no evidence for a direct relationship between Hcy plasma levels and cognitive impairment and dementia in PD. No indirect effect through cerebrovascular disease or genetic background was found either.

Affiliations:

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 000D97
to stream PascalFrancis, to step Curation: 001F22
to stream PascalFrancis, to step Checkpoint: 000E51
to stream Main, to step Merge: 002F48
to stream Main, to step Curation: 002515

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Homocysteine and Cognitive Impairment in Parkinson's Disease: A Biochemical, Neuroimaging, and Genetic Study</title>
<author><name sortKey="Rodriguez Oroz, Mariac" sort="Rodriguez Oroz, Mariac" uniqKey="Rodriguez Oroz M" first="Mariac." last="Rodriguez-Oroz">Mariac. Rodriguez-Oroz</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University Clinic and Medical School of Navarra</s1>
<s2>Pamplona</s2>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Pamplona</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Neuroscience Center, CIMA</s1>
<s2>Pamplona</s2>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Pamplona</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Centros de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)</s1>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Centros de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Martinez Lage, Pablo" sort="Martinez Lage, Pablo" uniqKey="Martinez Lage P" first="Pablo" last="Martinez Lage">Pablo Martinez Lage</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University Clinic and Medical School of Navarra</s1>
<s2>Pamplona</s2>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Pamplona</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sanchez Mut, Jose" sort="Sanchez Mut, Jose" uniqKey="Sanchez Mut J" first="Jose" last="Sanchez-Mut">Jose Sanchez-Mut</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Unitat de Genética Molecular, Institut de Biomedicina de València-CSIC</s1>
<s2>Valencia</s2>
<s3>ESP</s3>
<sZ>3 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Valencia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lamet, Isabel" sort="Lamet, Isabel" uniqKey="Lamet I" first="Isabel" last="Lamet">Isabel Lamet</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University Clinic and Medical School of Navarra</s1>
<s2>Pamplona</s2>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Pamplona</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pagonabarraga, Javier" sort="Pagonabarraga, Javier" uniqKey="Pagonabarraga J" first="Javier" last="Pagonabarraga">Javier Pagonabarraga</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Centros de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)</s1>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Centros de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Department of Neurology, Hospital Sant Pau</s1>
<s2>Barcelona</s2>
<s3>ESP</s3>
<sZ>5 aut.</sZ>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Toledo, Jon B" sort="Toledo, Jon B" uniqKey="Toledo J" first="Jon B." last="Toledo">Jon B. Toledo</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University Clinic and Medical School of Navarra</s1>
<s2>Pamplona</s2>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Pamplona</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Garcia Garcia, David" sort="Garcia Garcia, David" uniqKey="Garcia Garcia D" first="David" last="Garcia-Garcia">David Garcia-Garcia</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University Clinic and Medical School of Navarra</s1>
<s2>Pamplona</s2>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Pamplona</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Neuroscience Center, CIMA</s1>
<s2>Pamplona</s2>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Pamplona</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Centros de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)</s1>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Centros de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Clavero, Pedro" sort="Clavero, Pedro" uniqKey="Clavero P" first="Pedro" last="Clavero">Pedro Clavero</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University Clinic and Medical School of Navarra</s1>
<s2>Pamplona</s2>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Pamplona</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Neuroscience Center, CIMA</s1>
<s2>Pamplona</s2>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Pamplona</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Centros de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)</s1>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Centros de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Samaranch, Lluis" sort="Samaranch, Lluis" uniqKey="Samaranch L" first="Lluis" last="Samaranch">Lluis Samaranch</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University Clinic and Medical School of Navarra</s1>
<s2>Pamplona</s2>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Pamplona</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Irurzun, Cecilia" sort="Irurzun, Cecilia" uniqKey="Irurzun C" first="Cecilia" last="Irurzun">Cecilia Irurzun</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University Clinic and Medical School of Navarra</s1>
<s2>Pamplona</s2>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Pamplona</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Matsubara, Juan M" sort="Matsubara, Juan M" uniqKey="Matsubara J" first="Juan M." last="Matsubara">Juan M. Matsubara</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University Clinic and Medical School of Navarra</s1>
<s2>Pamplona</s2>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Pamplona</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Irigoien, Jaione" sort="Irigoien, Jaione" uniqKey="Irigoien J" first="Jaione" last="Irigoien">Jaione Irigoien</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University Clinic and Medical School of Navarra</s1>
<s2>Pamplona</s2>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Pamplona</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bescos, Emilia" sort="Bescos, Emilia" uniqKey="Bescos E" first="Emilia" last="Bescos">Emilia Bescos</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University Clinic and Medical School of Navarra</s1>
<s2>Pamplona</s2>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Pamplona</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kulisevsky, Jaime" sort="Kulisevsky, Jaime" uniqKey="Kulisevsky J" first="Jaime" last="Kulisevsky">Jaime Kulisevsky</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Centros de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)</s1>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Centros de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Department of Neurology, Hospital Sant Pau</s1>
<s2>Barcelona</s2>
<s3>ESP</s3>
<sZ>5 aut.</sZ>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Perez Tur, Jordi" sort="Perez Tur, Jordi" uniqKey="Perez Tur J" first="Jordi" last="Perez-Tur">Jordi Perez-Tur</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Centros de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)</s1>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Centros de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Unitat de Genética Molecular, Institut de Biomedicina de València-CSIC</s1>
<s2>Valencia</s2>
<s3>ESP</s3>
<sZ>3 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Valencia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Obeso, Jose A" sort="Obeso, Jose A" uniqKey="Obeso J" first="Jose A." last="Obeso">Jose A. Obeso</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University Clinic and Medical School of Navarra</s1>
<s2>Pamplona</s2>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Pamplona</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Neuroscience Center, CIMA</s1>
<s2>Pamplona</s2>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Pamplona</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Centros de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)</s1>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Centros de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">09-0358934</idno>
<date when="2009">2009</date>
<idno type="stanalyst">PASCAL 09-0358934 INIST</idno>
<idno type="RBID">Pascal:09-0358934</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000D97</idno>
<idno type="wicri:Area/PascalFrancis/Curation">001F22</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000E51</idno>
<idno type="wicri:doubleKey">0885-3185:2009:Rodriguez Oroz M:homocysteine:and:cognitive</idno>
<idno type="wicri:Area/Main/Merge">002F48</idno>
<idno type="wicri:Area/Main/Curation">002515</idno>
<idno type="wicri:Area/Main/Exploration">002515</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Homocysteine and Cognitive Impairment in Parkinson's Disease: A Biochemical, Neuroimaging, and Genetic Study</title>
<author><name sortKey="Rodriguez Oroz, Mariac" sort="Rodriguez Oroz, Mariac" uniqKey="Rodriguez Oroz M" first="Mariac." last="Rodriguez-Oroz">Mariac. Rodriguez-Oroz</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University Clinic and Medical School of Navarra</s1>
<s2>Pamplona</s2>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Pamplona</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Neuroscience Center, CIMA</s1>
<s2>Pamplona</s2>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Pamplona</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Centros de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)</s1>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Centros de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Martinez Lage, Pablo" sort="Martinez Lage, Pablo" uniqKey="Martinez Lage P" first="Pablo" last="Martinez Lage">Pablo Martinez Lage</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University Clinic and Medical School of Navarra</s1>
<s2>Pamplona</s2>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Pamplona</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sanchez Mut, Jose" sort="Sanchez Mut, Jose" uniqKey="Sanchez Mut J" first="Jose" last="Sanchez-Mut">Jose Sanchez-Mut</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Unitat de Genética Molecular, Institut de Biomedicina de València-CSIC</s1>
<s2>Valencia</s2>
<s3>ESP</s3>
<sZ>3 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Valencia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lamet, Isabel" sort="Lamet, Isabel" uniqKey="Lamet I" first="Isabel" last="Lamet">Isabel Lamet</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University Clinic and Medical School of Navarra</s1>
<s2>Pamplona</s2>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Pamplona</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pagonabarraga, Javier" sort="Pagonabarraga, Javier" uniqKey="Pagonabarraga J" first="Javier" last="Pagonabarraga">Javier Pagonabarraga</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Centros de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)</s1>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Centros de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Department of Neurology, Hospital Sant Pau</s1>
<s2>Barcelona</s2>
<s3>ESP</s3>
<sZ>5 aut.</sZ>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Toledo, Jon B" sort="Toledo, Jon B" uniqKey="Toledo J" first="Jon B." last="Toledo">Jon B. Toledo</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University Clinic and Medical School of Navarra</s1>
<s2>Pamplona</s2>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Pamplona</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Garcia Garcia, David" sort="Garcia Garcia, David" uniqKey="Garcia Garcia D" first="David" last="Garcia-Garcia">David Garcia-Garcia</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University Clinic and Medical School of Navarra</s1>
<s2>Pamplona</s2>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Pamplona</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Neuroscience Center, CIMA</s1>
<s2>Pamplona</s2>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Pamplona</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Centros de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)</s1>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Centros de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Clavero, Pedro" sort="Clavero, Pedro" uniqKey="Clavero P" first="Pedro" last="Clavero">Pedro Clavero</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University Clinic and Medical School of Navarra</s1>
<s2>Pamplona</s2>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Pamplona</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Neuroscience Center, CIMA</s1>
<s2>Pamplona</s2>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Pamplona</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Centros de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)</s1>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Centros de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Samaranch, Lluis" sort="Samaranch, Lluis" uniqKey="Samaranch L" first="Lluis" last="Samaranch">Lluis Samaranch</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University Clinic and Medical School of Navarra</s1>
<s2>Pamplona</s2>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Pamplona</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Irurzun, Cecilia" sort="Irurzun, Cecilia" uniqKey="Irurzun C" first="Cecilia" last="Irurzun">Cecilia Irurzun</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University Clinic and Medical School of Navarra</s1>
<s2>Pamplona</s2>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Pamplona</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Matsubara, Juan M" sort="Matsubara, Juan M" uniqKey="Matsubara J" first="Juan M." last="Matsubara">Juan M. Matsubara</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University Clinic and Medical School of Navarra</s1>
<s2>Pamplona</s2>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Pamplona</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Irigoien, Jaione" sort="Irigoien, Jaione" uniqKey="Irigoien J" first="Jaione" last="Irigoien">Jaione Irigoien</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University Clinic and Medical School of Navarra</s1>
<s2>Pamplona</s2>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Pamplona</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bescos, Emilia" sort="Bescos, Emilia" uniqKey="Bescos E" first="Emilia" last="Bescos">Emilia Bescos</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University Clinic and Medical School of Navarra</s1>
<s2>Pamplona</s2>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Pamplona</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kulisevsky, Jaime" sort="Kulisevsky, Jaime" uniqKey="Kulisevsky J" first="Jaime" last="Kulisevsky">Jaime Kulisevsky</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Centros de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)</s1>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Centros de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Department of Neurology, Hospital Sant Pau</s1>
<s2>Barcelona</s2>
<s3>ESP</s3>
<sZ>5 aut.</sZ>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Perez Tur, Jordi" sort="Perez Tur, Jordi" uniqKey="Perez Tur J" first="Jordi" last="Perez-Tur">Jordi Perez-Tur</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Centros de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)</s1>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Centros de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Unitat de Genética Molecular, Institut de Biomedicina de València-CSIC</s1>
<s2>Valencia</s2>
<s3>ESP</s3>
<sZ>3 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Valencia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Obeso, Jose A" sort="Obeso, Jose A" uniqKey="Obeso J" first="Jose A." last="Obeso">Jose A. Obeso</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University Clinic and Medical School of Navarra</s1>
<s2>Pamplona</s2>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Pamplona</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Neuroscience Center, CIMA</s1>
<s2>Pamplona</s2>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Pamplona</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Centros de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)</s1>
<s3>ESP</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Centros de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2009">2009</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cognitive disorder</term>
<term>Dementia</term>
<term>Homocystein</term>
<term>Hyperintensity</term>
<term>Nervous system diseases</term>
<term>Parkinson disease</term>
<term>White matter</term>
<term>mild cognitive impairment</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Trouble cognitif</term>
<term>Maladie de Parkinson</term>
<term>Démence</term>
<term>Déficit cognitif léger</term>
<term>Pathologie du   système nerveux</term>
<term>Homocystéine</term>
<term>Substance blanche</term>
<term>Hyperintensité</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The role of the plasma level of homocysteine (Hcy), as a primary outcome, and the effect of silent cerebrovascular lesions and genetic variants related to Hcy metabolism, as secondary outcomes, in the cognitive decline and dementia in Parkinson's disease (PD) were studied. This casecontrol study focused on 89 PD patients of minimum 10 years of evolution and older than 60 years, who were neuro-psychologically classified either as cognitively normal (n = 37), having mild cognitive impairment (Petersen criteria) (n = 22), or suffering from dementia (DSM-IV) (n = 30), compared with cognitively normal age-matched control subjects (n = 30). Plasma levels of Hcy, vitamins B12 and B6, folic acid, polymorphisms in genes related to Hcy metabolism (MTHFR, MTR, MTRR, and CBS) and silent cerebrovascular events were analyzed. Plasma levels of Hcy were increased in PD patients (P = 0.0001). There were no differences between the groups of patients. The brain vascular burden was similar among PD groups. There was no association between polymorphisms in the studied genes and the Hcy plasma levels or cognitive status in PD patients. We found no evidence for a direct relationship between Hcy plasma levels and cognitive impairment and dementia in PD. No indirect effect through cerebrovascular disease or genetic background was found either.</div>
</front>
</TEI>
<affiliations><list><country><li>Espagne</li>
</country>
<region><li>Catalogne</li>
</region>
<settlement><li>Barcelone</li>
</settlement>
</list>
<tree><country name="Espagne"><noRegion><name sortKey="Rodriguez Oroz, Mariac" sort="Rodriguez Oroz, Mariac" uniqKey="Rodriguez Oroz M" first="Mariac." last="Rodriguez-Oroz">Mariac. Rodriguez-Oroz</name>
</noRegion>
<name sortKey="Bescos, Emilia" sort="Bescos, Emilia" uniqKey="Bescos E" first="Emilia" last="Bescos">Emilia Bescos</name>
<name sortKey="Clavero, Pedro" sort="Clavero, Pedro" uniqKey="Clavero P" first="Pedro" last="Clavero">Pedro Clavero</name>
<name sortKey="Clavero, Pedro" sort="Clavero, Pedro" uniqKey="Clavero P" first="Pedro" last="Clavero">Pedro Clavero</name>
<name sortKey="Clavero, Pedro" sort="Clavero, Pedro" uniqKey="Clavero P" first="Pedro" last="Clavero">Pedro Clavero</name>
<name sortKey="Garcia Garcia, David" sort="Garcia Garcia, David" uniqKey="Garcia Garcia D" first="David" last="Garcia-Garcia">David Garcia-Garcia</name>
<name sortKey="Garcia Garcia, David" sort="Garcia Garcia, David" uniqKey="Garcia Garcia D" first="David" last="Garcia-Garcia">David Garcia-Garcia</name>
<name sortKey="Garcia Garcia, David" sort="Garcia Garcia, David" uniqKey="Garcia Garcia D" first="David" last="Garcia-Garcia">David Garcia-Garcia</name>
<name sortKey="Irigoien, Jaione" sort="Irigoien, Jaione" uniqKey="Irigoien J" first="Jaione" last="Irigoien">Jaione Irigoien</name>
<name sortKey="Irurzun, Cecilia" sort="Irurzun, Cecilia" uniqKey="Irurzun C" first="Cecilia" last="Irurzun">Cecilia Irurzun</name>
<name sortKey="Kulisevsky, Jaime" sort="Kulisevsky, Jaime" uniqKey="Kulisevsky J" first="Jaime" last="Kulisevsky">Jaime Kulisevsky</name>
<name sortKey="Kulisevsky, Jaime" sort="Kulisevsky, Jaime" uniqKey="Kulisevsky J" first="Jaime" last="Kulisevsky">Jaime Kulisevsky</name>
<name sortKey="Lamet, Isabel" sort="Lamet, Isabel" uniqKey="Lamet I" first="Isabel" last="Lamet">Isabel Lamet</name>
<name sortKey="Martinez Lage, Pablo" sort="Martinez Lage, Pablo" uniqKey="Martinez Lage P" first="Pablo" last="Martinez Lage">Pablo Martinez Lage</name>
<name sortKey="Matsubara, Juan M" sort="Matsubara, Juan M" uniqKey="Matsubara J" first="Juan M." last="Matsubara">Juan M. Matsubara</name>
<name sortKey="Obeso, Jose A" sort="Obeso, Jose A" uniqKey="Obeso J" first="Jose A." last="Obeso">Jose A. Obeso</name>
<name sortKey="Obeso, Jose A" sort="Obeso, Jose A" uniqKey="Obeso J" first="Jose A." last="Obeso">Jose A. Obeso</name>
<name sortKey="Obeso, Jose A" sort="Obeso, Jose A" uniqKey="Obeso J" first="Jose A." last="Obeso">Jose A. Obeso</name>
<name sortKey="Pagonabarraga, Javier" sort="Pagonabarraga, Javier" uniqKey="Pagonabarraga J" first="Javier" last="Pagonabarraga">Javier Pagonabarraga</name>
<name sortKey="Pagonabarraga, Javier" sort="Pagonabarraga, Javier" uniqKey="Pagonabarraga J" first="Javier" last="Pagonabarraga">Javier Pagonabarraga</name>
<name sortKey="Perez Tur, Jordi" sort="Perez Tur, Jordi" uniqKey="Perez Tur J" first="Jordi" last="Perez-Tur">Jordi Perez-Tur</name>
<name sortKey="Perez Tur, Jordi" sort="Perez Tur, Jordi" uniqKey="Perez Tur J" first="Jordi" last="Perez-Tur">Jordi Perez-Tur</name>
<name sortKey="Rodriguez Oroz, Mariac" sort="Rodriguez Oroz, Mariac" uniqKey="Rodriguez Oroz M" first="Mariac." last="Rodriguez-Oroz">Mariac. Rodriguez-Oroz</name>
<name sortKey="Rodriguez Oroz, Mariac" sort="Rodriguez Oroz, Mariac" uniqKey="Rodriguez Oroz M" first="Mariac." last="Rodriguez-Oroz">Mariac. Rodriguez-Oroz</name>
<name sortKey="Samaranch, Lluis" sort="Samaranch, Lluis" uniqKey="Samaranch L" first="Lluis" last="Samaranch">Lluis Samaranch</name>
<name sortKey="Sanchez Mut, Jose" sort="Sanchez Mut, Jose" uniqKey="Sanchez Mut J" first="Jose" last="Sanchez-Mut">Jose Sanchez-Mut</name>
<name sortKey="Toledo, Jon B" sort="Toledo, Jon B" uniqKey="Toledo J" first="Jon B." last="Toledo">Jon B. Toledo</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002515 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002515 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Santé
   |area=    MovDisordV3
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     Pascal:09-0358934
   |texte=   Homocysteine and Cognitive Impairment in Parkinson's Disease: A Biochemical, Neuroimaging, and Genetic Study
}}

This area was generated with Dilib version V0.6.23.
Data generation: Sun Jul 3 12:29:32 2016. Site generation: Wed Feb 14 10:52:30 2024

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Movement Disorders (revue)

Homocysteine and Cognitive Impairment in Parkinson's Disease: A Biochemical, Neuroimaging, and Genetic Study

Homocysteine and Cognitive Impairment in Parkinson's Disease: A Biochemical, Neuroimaging, and Genetic Study

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri